Ä´ºº¡¦¸¡Æ¤ÂоÝ

  1. ¥Û¡¼¥à
  2. Ä´ºº¡¦¸¡Æ¤ÂоÝ

SSRI¡ÊÁªÂòŪ¥»¥í¥È¥Ë¥óºÆ¼è¤ê¹þ¤ßÁ˳²ºÞ¡Ë¡Ë

1 SSRI¤È¤Ï

ÁªÂòŪ¥»¥í¥È¥Ë¥óºÆ¼è¤ê¹þ¤ßÁ˳²ºÞ (Selective Serotonin Reuptake Inhibitor) ¤ÎƬʸ»ú¤ò¼è¤Ã¤¿Î¬¾Î¤Ç¡¢¹³¤¦¤ÄºîÍÑ¡¢¹³É԰¾㳲ºîÍѤòÍ­¤¹¤ë¤È¤µ¤ì¤Æ¤¤¤ë°åÌôÉʤǤ¢¤ë¡£ÆüËܤǤϡ¢¤¦¤ÄÉ¡¦¤¦¤Ä¾õÂ֤˲䨡¢¥Ñ¥Ë¥Ã¥¯¾ã³²¡¢¶¯Ç÷À­¾ã³²¡¢¼Ò²ñÉ԰¾㳲Åù¤ÎÉ԰¾㳲Îΰè¤Ø¤ÎŬ±þ³ÈÂ礬¹Ô¤ï¤ì¤Æ¤¤¤ë¡£½¾Íè¤Î»°´Ä·Ï¤ä»Í´Ä·Ï¤Î¹³¤¦¤ÄÌô¤È°Û¤Ê¤ê¡¢¥»¥í¥È¥Ë¥ó·Ï¤ËÁªÂòŪ¤ËºîÍѤ¹¤ë¤«¤Î¤è¤¦¤Ë¥á¡¼¥«¡¼¤ä°ìÉôÀìÌç°å¡¦¥Þ¥¹¥³¥ßÅù¤òÄ̤¸¤ÆÀëÅÁ¤µ¤ì¡¢¡ÖÉûºîÍѤ¬¾¯¤Ê¤¯°ìÈÌÎ×¾²°å¤Ç¤â»È¤¨¤ë¿·¤·¤¤¥¿¥¤¥×¤ÎÌô¡×¤È¤Î¥¤¥á¡¼¥¸¤¬°åΟ½¾ì¤Ç·ÁÀ®¤µ¤ì¡¢Àº¿À²ÊÀìÌç°å°Ê³°¤Î°ìÈÌÎ×¾²°å¤Ë¤è¤ë½èÊý¤¬µÞ³ÈÂ礷¤Æ¤¤¤ë¡£
1988ǯ¤Ë¥¤¡¼¥é¥¤¡¦¥ê¥ê¡¼¼Ò¤¬Êƹñ¤Ç¾µÇ§¤ò¼õ¤±¤¿¥×¥í¥¶¥Ã¥¯¡Ê°ìÈÌ̾¡§¥Õ¥ë¥ª¥­¥»¥Á¥ó¡¢ÆüËṲ̈ȯÇä¡Ë¤¬ÂåɽŪ¾¦ÉʤÀ¤¬¡¢¸½ºß¤Ç¤Ï¥°¥é¥¯¥½¡¦¥¹¥ß¥¹¥¯¥é¥¤¥ó¼Ò¤Î¥Ñ¥­¥·¥ë¡Ê°ìÈÌ̾¡§±ö»À¥Ñ¥í¥­¥»¥Á¥ó¿åÏÂʪ¡¢±Ñ¹ñ¤Ç¤Î¾¦ÉÊ̾¤Ï¥»¥í¥­¥µ¡¼¥È¡Ë¡¢¥Õ¥¡¥¤¥¶¡¼¼Ò¤Î¥¸¥§¥¤¥¾¥í¥Õ¥È¡Ê°ìÈÌ̾¡§±ö»À¥»¥ë¥È¥é¥ê¥ó¡¢±Ñ¹ñ¤Ç¤Î¾¦ÉÊ̾¤Ï¥¾¥í¥Õ¥È¡Ë¤¬¹­¤¯³Æ¹ñ¤Ç»ÈÍѤµ¤ì¤Æ¤¤¤ë¡£
ÆüËܤǤϡ¢1999ǯ5·î¤«¤éȯÇ䳫»Ï¤µ¤ì¡¢¸½ºß¤Ï①¥ë¥Ü¥Ã¥¯¥¹¡Ê°ìÈÌ̾¡§¥Þ¥ì¥¤¥ó»À¥Õ¥ë¥Ü¥­¥µ¥ß¥ó¡¢¥¢¥¹¥Æ¥é¥¹À½Ìô³ô¼°²ñ¼Ò¡Ë¡¢②¥Ç¥×¥í¥á¡¼¥ë¡Ê°ìÈÌ̾¡§Æ±º¸¡¢ÌÀ¼£À½²Û³ô¼°²ñ¼Ò¡Ë¡¢③¥Ñ¥­¥·¥ë¡Ê°ìÈÌ̾¡§¥Ñ¥í¥­¥»¥Á¥ó±ö»À±ö¿åÏÂʪ¡¢¥°¥é¥¯¥½¡¦¥¹¥ß¥¹¥¯¥é¥¤¥ó³ô¼°²ñ¼Ò)¡¢④¥¸¥§¥¤¥¾¥í¥Õ¥È¡Ê°ìÈÌ̾¡§±ö»À¥»¥ë¥È¥é¥ê¥ó¡¢¥Õ¥¡¥¤¥¶¡¼³ô¼°²ñ¼Ò¡Ë¤¬È¯Ç䤵¤ì¤Æ¤¤¤ë¡£¤Þ¤¿¡¢Îà»÷Ìô¤ÎSNRI¡ÊÁªÂòŪ¥»¥í¥È¥Ë¥ó¡¦¥Î¥ë¥¢¥É¥ì¥Ê¥ê¥óºÆ¼è¤ê¹þ¤ßÁ˳²ºÞ¡Ë¤Ç¤¢¤ë¥È¥ì¥É¥ß¥ó¡Ê°ìÈÌ̾¡§±ö»À¥ß¥ë¥Ê¥·¥×¥é¥ó¡¢°°²½À®¥Õ¥¡¡¼¥Þ³ô¼°²ñ¼Ò¡¢¥ä¥ó¥»¥ó¥Õ¥¡¡¼¥Þ³ô¼°²ñ¼Ò¡Ë¤âȯÇ䤵¤ì¤Æ¤¤¤ë¡£
ÈÎÇä³Û¡ÊÌô²Á¥Ù¡¼¥¹¡Ë¤ÏSNRI¤ò¹ç¤ï¤»¤ë¤È¡¢2003ǯÅÙ¤Ï540²¯±ß¡Ê¥Ñ¥­¥·¥ë¡§310²¯±ß¡Ë¡¢2005ǯÅÙ¤Ï730²¯±ß¡Ê¥Ñ¥­¥·¥ë¡§450²¯±ß¡Ë¡¢2007ǯÅ٤ˤÏ900²¯±ß¡Ê¥Ñ¥­¥·¥ë¡§590²¯±ß¡Ë¤ÈµÞÁý¤·¤Æ¤ª¤ê¡¢»ÈÍѤ¬¸º¾¯¤·¤Æ¤¤¤ë²¤ÊƤȤϸ²Ãø¤Ê°ã¤¤¤ò¤ß¤»¤Æ¤¤¤ë¡£

2 ¤È¤ê¤¢¤²¤¿·Ð°Þ

SSRI¡¢¤È¤ê¤ï¤±¥Ñ¥­¥·¥ë¤Ë¤Ä¤¤¤Æ¤Ï¡¢Êƹñ¡¦±Ñ¹ñ¤Ç¤ÎΥæȿ±þ¡¢¼«»¦´ë¿Þ¡¢µõµ¶ÀëÅÁ¤Ê¤É¤ò¤á¤°¤ëÁʾ٤¬µ¯¤³¤µ¤ì¤Æ¤¤¤ë¤Û¤«¡¢±Ñ¹ñ¤Ç¤ÎBBCÊüÁ÷¥Ë¥å¡¼¥¹Æý¸ÈÖÁȥѥΥé¥Þ¤ä¥Á¥ã¡¼¥ë¥º¡¦¥á¥À¥ï¡¼¡Ê»Ô̱ÃÄÂÎ¥½¡¼¥·¥ã¥ë¡¦¥ª¡¼¥Ç¥£¥Ã¥ÈÂåɽ¡Ë¡¢¥¢¥ó¥É¥ê¥å¡¼¡¦¥Ø¥ë¥¯¥¹¥Þ¥¤¥ä¡¼¡Ê°å»Õ¡Ë¡¢¥Ç¡¼¥Ó¥Ã¥È¡¦¥Ò¡¼¥ê¡¼¡ÊÀº¿À²Ê°å¡Ë¤Ê¤É¤Ë¤è¤ëSSRIÈï³²¤Î·¡¤êµ¯¤³¤·¤È¹ÔÀ¯¤Ø¤ÎÀºÎÏŪ¤ÊƯ¤­¤«¤±¤¬¤¢¤ë¡£¤Þ¤¿¡¢¥Ñ¥­¥·¥ë¤Î¥Æ¥£¡¼¥ó¥¨¥¤¥¸¥ã¡¼¤Ø¤ÎÍ­¸úÀ­¤¬Ìµ¤¤¤³¤È¤ä¡¢¼«»¦´ë¿Þ¤Ê¤É¤Î½ÅÆƤÊÍ­³²ºîÍѤθºß¤ò΢ÉÕ¤±¤ë¥Ç¡¼¥¿¤ò¥°¥é¥¯¥½¡ÊGSK¡Ë¼Ò¤¬±£¤·¤Æ¤¤¤¿¤È¤·¤ÆÊƹñ¥Ë¥å¡¼¥è¡¼¥¯½£Åö¶É¤¬ÄóÁʤ¹¤ë¤Ê¤É¡¢SSRI¤ÎÍ­³²ºîÍѤä»È¤ï¤ìÊý¤ÎÌäÂê¤Ï¡¢²¤ÊƤǤÏÂ礭¤Ê¼Ò²ñÌäÂê¤È¤Ê¤Ã¤Æ¤¤¤ë¡£
¤·¤«¤·¡¢ÆüËܤǤϤ³¤ì¤é¤Î»ö¼Â¤Ï¤Û¤È¤ó¤ÉÃΤé¤ì¤Æ¤ª¤é¤º¡¢SSRI¤ÏÍ­³²ºîÍѤ¬¾¯¤Ê¤¯¡¢°ìÈÌ°å¤Ç¤â»È¤¤¤ä¤¹¤¤¹³¤¦¤ÄºÞ¤È¤·¤Æ½èÊý¤¬Áý²Ã¤·¡¢¥ê¥¹¥È¥é¤Ê¤ÉÀ¸³èÉ԰¡¢Êĺɴ¶¤Î¤¢¤ë¼Ò²ñ¾õ¶·¤È¤â´ØÏ¢¤·¤Æ¡¢Â礭¤¯Çä¤ê¾å¤²¤ò¿­¤Ð¤·¤Æ¤¤¤ë¡£
¤³¤Î²¤ÊƤÈÆüËܤξõ¶·¤Î¥®¥ã¥Ã¥×¤ÎÂ礭¤µ¤Ë¤âÃíÌܤ·¡¢ÆüËܤˤª¤±¤ëËܺޤò¤á¤°¤ëÌäÂêÅÀ¤òÌÀ¤é¤«¤Ë¤¹¤Ù¤¯¼è¤ê¾å¤²¤ë¤³¤È¤È¤·¤¿¡£

3 ²¿¤¬ÌäÂ꤫

SSRI¤Ï½¾Íè¤Î»°´Ä·Ï¤ä»Í´Ä·Ï¤Î¹³¤¦¤ÄÌô¤È¸ú²Ì¤ÏƱ¤¸¤À¤¬¡¢¥»¥í¥È¥Ë¥ó·Ï¤ËÁªÂòŪ¤ËºîÍѤ¹¤ë¤¿¤á°ÂÁ´À­¤¬¹â¤¯»È¤¤¤ä¤¹¤¤Ìô¤È¤Î¥¤¥á¡¼¥¸¤¬°åΟ½¾ì¤Ç·ÁÀ®¤µ¤ì¤Æ¤¤¤ë¡£³Î¤«¤Ë¹³¥³¥ê¥óºîÍѤ乳¥Ò¥¹¥¿¥ß¥óºîÍѤ¬¼å¤¤¤¿¤áǦÍÆÀ­¤¬¹â¤¯¡¢²áÎÌÉþÍѤκݤÎÃ×»àΨ¤¬Ä㤯¿´ÆÇÀ­¤Ï¾¯¤Ê¤¤¡£¤·¤«¤·¡¢SSRI¤Ë¤ÏÈó¾ï¤ËÃí°Õ¤µ¤ì¤ëÍ­³²ºîÍѤ¬Â¸ºß¤¹¤ë¡£²¤ÊƤÇÌäÂê¤È¤Ê¤Ã¤¿¼«»¦¤ä¼«»¦¹Ô°Ù¡¢¹¶·âÀ­¤Ê¤É¤Î¾×Æ°À­Ð¶¿Ê¡¢Î¥Ã¦¡Ê¶ØÃǡ˾ɸõ·²¤È°Í¸À­¤ÎÌäÂê¡¢ÅêÍ¿´µ¼Ô¤Î6³ä°Ê¾å¤Ëȯ¸½¤¹¤ëÀ­µ¡Ç½¾ã³²¡¢¾ïÍÑÎÌÈϰϤǤÎÂÛ»ùÆÇÀ­¡Ê½ÐÀ¸»þ¤ÎÂνŸº¾¯¡¢¤±¤¤¤ì¤óȯºîͶȯ¡¢Î¥Ã¦¾É¸õ·²Í¶È¯¤Ê¤É¡Ë¡¢½¾Íè·¿¡Ö¹³¤¦¤ÄÌô¡×¤Ç¤Ï¸«¤é¤ì¤Ê¤¤¹üÀÞ¤ä¹üÌ©ÅÙ¸º¾¯¡¢¾Ã²½´É½Ð·ì¡ÖÌäÂê¡×¤Ê¤É¿´ô¤Ë¤ï¤¿¤ëÍ­³²ºîÍѤ¬¤¢¤ë¡£
À¯ÉܤΡּ«»¦Âкö´ðËÜË¡¡×¤Î»Ü¹Ô¡Ê2006ǯ10·î¡Ë¤ä¡Ö¼«»¦Áí¹çÂкöÂç¹Ë¡×¤ÎºöÄê¡Ê2007ǯ6·î¡Ë¤Ê¤É¡¢¹ñ¤òµó¤²¤¿¼«»¦Í½ËÉÂкö¤¬Ëܳʲ½¤¹¤ëÃæ¡¢¤¦¤ÄɤòÁá´ü¤Ëȯ¸«¤·¼£ÎŤ¹¤ë¼è¤êÁȤߤ¬¹Ô¤ï¤ì¡¢·Ú¾É¤Î¤¦¤ÄɤϰìḚ̀夬¼£ÎŤ¹¤ë¤È¤¤¤¦Î®¤ì¤¬¶¯¤Þ¤Ã¤Æ¤¤¤ë¡£¤½¤Î·ë²Ì¡¢°ìÈÌ°å¤Ë¤è¤ë·Ú¾É¤¦¤Äɼ£ÎŤÎÂè°ìÁªÂò¤È¤·¤Æ¡¢°Â°×¤ËSSRI¤Ë¤è¤ëÌôʪÎÅË¡¤¬¹Ô¤ï¤ì¤ë²ÄǽÀ­¤¬¹â¤¤¡£ÆäËSSRI¤ÎÍ­³²ºîÍѤǤ¢¤ë¾×Æ°À­Ð¶¿Ê¤ÈÀ­µ¡Ç½¾ã³²¤Ï¤¦¤Äɤ˿ïȼ¤¹¤ë¾É¾õ¤È¤Î´ÕÊ̤¬º¤Æñ¤Ç¤¢¤ê¡¢ÅºÉÕʸ½ñ¾å¤Îµ­ºÜ¤âÉÔ½½Ê¬¤Ê¤¿¤á¡¢Í­³²»ö¾Ý¤ò¤ß¤¹¤´¤·¡¢»ÈÍѤ¬·Ñ³¤µ¤ìÈï³²¤¬³ÈÂ礹¤ë¤ª¤½¤ì¤¬¤¢¤ë¡£

4 ´ðËÜŪ¤Ê¹ÔÆ°Êý¿Ë

¥á¥Ç¥£¥«¥ê¥¼¡¼¥·¥ç¥ó¡Ê°åÎŲ½¡¢ÌôÄÒ¤±°åΚˤȸƤФì¤ëŬÀڤǤʤ¤´µ¼Ô¤äÌôʪ¼£ÎŤòɬÍפȤ·¤Ê¤¤»Ô̱¤Ø¤Î»ÈÍѤ¬ÌÜΩ¤ÄSSRI¤Ç¤¢¤ë¤¬¡¢SSRI¤ÏΥæȿ±þ¤ÎÌäÂê¤â¤¢¤Ã¤Æ¡Ö°ìÈÌÎ×¾²°å¤¬°Â¿´¤·¤Æ»È¤¨¤ë°åÌôÉʡפǤϷ褷¤Æ̵¤¯¡¢¡ÖÈó¾ï¤Ë¤ä¤Ã¤«¤¤¤Ê°åÌôÉʡפǤ¢¤ê¡¢ÈÎÇ䤬·Ñ³¤µ¤ì¤ë¤È¤·¤Æ¤âÀìÌç°å¤Ë¤è¤ë¸ÂÄꤷ¤¿»ÈÍѤ¬µá¤á¤é¤ì¤ë°åÌôÉʤǤ¢¤ë¡£SSRI¤ÎÍ­³²ºîÍѤ¬°ìÈÌ°å¤Ë¤âÀµ¤·¤¯Ç§¼±¤µ¤ì¤ë¤è¤¦¤Ë·¼È¯¡¢ÌäÂêÄ󵯤ò¹Ô¤Ã¤Æ¤¤¤¯¡£

5 ¶ñÂÎŪ¹ÔÆ°¤È¤½¤Î·ë²Ì

  1. (1) 2004ǯ10·î27Æü¡¢¥°¥é¥¯¥½¡¦¥¹¥ß¥¹¥¯¥é¥¤¥ó¡ÊÆüËÜË¡¿Í¡Ë¡¢Æ£ÂôÌôÉʹ©¶È¡Ê¸½¥¢¥¹¥Æ¥é¥¹¡Ë¡¢ÌÀ¼£À½²Û¤¢¤Æ¡¢¡Ö¹³¤¦¤ÄºÞSSRI¤Î¥Ç¡¼¥¿Åù¤Î¸ø³«¤òµá¤á¤ëÍ×˾½ñ¡×¤òÁ÷ÉÕ¡¢¸üÏ«¾Ê¤Ë¤Ï¤³¤ì¤é¤Î¼Ì¤·¤òÁ÷ÉÕ¤·¤¿¡£¤³¤ì¤ËÂФ·¡¢3¼Ò¤È¥½¥ë¥Ù¥¤À½Ìô¤«¤é²óÅú¤¬¤è¤»¤é¤ì¤¿¤¬¡¢Ëþ­¤Ç¤­¤ë²óÅú¤Ç¤Ï¤Ê¤«¤Ã¤¿¡£
  2. (2) 2004ǯ11·î23Æü¡¢Åö²ñµÄ¤ÈTIP¡ÖÀµ¤·¤¤¼£ÎŤÈÌô¤Î¾ðÊó¡×»ï¤Î¶¦ºÅ¤Ç¡¢¥½¡¼¥·¥ã¥ë¥ª¡¼¥Ç¥£¥Ã¥È¤Î¥Á¥ã¡¼¥ë¥º¡¦¥á¥À¥ï¡¼Âåɽ¤ò·Þ¤¨¤Æ¡¢Åìµþ¡¦KDDI¥Û¡¼¥ë¤Ç¥»¥ß¥Ê¡¼¡Ö˽Áö¤¹¤ë¥¯¥¹¥ê-º£¡¢¹³¤¦¤ÄºÞ¤Ç²¿¤¬µ¯¤­¤Æ¤¤¤ë¤Î¤«¡©¡×¤ò³«ºÅ¤·¤¿¡£¹­¤¤²ñ¾ì¤ÏͽÁÛ¤òĶ¤¨¤¿Â¿¤¯¤ÎÄ°½°¤ÇËä¤Þ¤ê¡¢¤³¤ÎÌäÂê¤Ø¤Î´Ø¿´¤Î¹â¤µ¤¬»Ç¤¨¤¿¡£
  3. (3) 2008ǯ5·î12Æü¡¢¸üÏ«¾Ê¡¢Ë¡Ì³¾Ê¡¢ÆüÊÛÏ¢¡¢¥¢¥¹¥Æ¥é¥¹À½Ìô¡¢ÌÀ¼£À½²Û¡¢¥°¥é¥¯¥½¡¦¥¹¥ß¥¹¥¯¥é¥¤¥ó³ô¼°²ñ¼Ò¡¢¥Õ¥¡¥¤¥¶¡¼³ô¼°²ñ¼Ò¤ËÂФ·¡¢¼ÂÂÖÇÄ°®¤¬º¤Æñ¤Ê¾×Æ°À­Ð¶¿Ê¤ÈÈȺá¤È¤Î´Ø·¸¤äÀ­µ¡Ç½¾ã³²¤Ë¤Ä¤¤¤Æ¤ÎÄ´ºº¼Â»Ü¡¢¤ª¤è¤ÓźÉÕʸ½ñ¤Î²þÄû¤òµá¤á¤ëÍ×˾½ñ¤òÄó½Ð¤·¡¢´ØÏ¢³Ø²ñ¤ËÂФ·¤Æ¼Ì¤·¤òÁ÷ÉÕ¤·¤¿¡£

¤³¤ÎÍ×˾½ñ¤ò¼õ¤±¤Æ¡¢ÆüÊÛÏ¢¤Ï¡¢2009ǯ4·î¤«¤é¡Ö¹³¤¦¤ÄÌô¡ÊSSRI¡¢SNRI¡Ë¤ÎÉûºîÍѤ˴ØÏ¢¤¹¤ë¤Èµ¿¤ï¤ì¤ë·º»ö¡¦¾¯Ç¯»ö·ï¤Ë´Ø¤¹¤ëÄ´ºº¡×¤ò³«»Ï¤·¤¿¡£ ¤Þ¤¿¡¢2009ǯ5·î¤Ë¤Ï¡¢¥Ñ¥­¥·¥ë¤ÎźÉÕʸ½ñ¤Î²þÄû¤¬¹Ô¤Ê¤ï¤ì¡¢¡Ö¿µ½ÅÅêÍ¿¡×¤Î¹àÌܤˡ־×Æ°À­¤¬¹â¤¤Ê»Â¸¾ã³²¤òÍ­¤¹¤ë´µ¼Ô¡×¤Ê¤É¤¬Äɲ䵤졢¡Ö½ÅÍפʴðËÜŪÃí°Õ¡×¤Î¹àÌܤâ¾×Æ°À­¡¢¹¶·âÀ­¡¢Â¾³²¹Ô°ÙÅù¤Ë´Ø¤¹¤ëÃí°Õ¤¬Äɲ䵤줿¡£

6 º£¸å¤Î²ÝÂê

º£¸å¤âSSRI¤Ë´Ø¤¹¤ë¾ðÊó¼ý½¸¤È·¼ÌسèÆ°¡¢SSRI¤Ç¸²Ãø¤Ê¥á¥Ç¥£¥«¥ê¥¼¡¼¥·¥ç¥ó¤Ë¤Ä¤¤¤Æ¤ÎÌäÂêÄ󵯤ʤɤò¹Ô¤Ã¤Æ¤¤¤¯¡£
¾×Æ°À­Ð¶¿Ê¤ÈÈȺá¤È¤Î´Ø·¸¤ÎÌäÂê¤Ë¤Ä¤¤¤Æ¤Ï¡¢ÊÛ¸î»Î²ñ¤Î¥¢¥ó¥±¡¼¥È·ë²Ì¤òƧ¤Þ¤¨¡¢¤µ¤é¤Ê¤ëÄó¸ÀÅù¤ò¹Ô¤Ê¤Ã¤Æ¤¤¤¯¡£¤Þ¤¿¡¢ÂÛ»ùÆÇÀ­¤Ë¤Ä¤¤¤Æ¤â¡¢¾ðÊó¼ý½¸¤Î¾å¡¢Ãí°Õ´­µ¯Åù¤ò¹Ô¤Ê¤Ã¤Æ¤¤¤¯¤³¤È¤ò¸¡Æ¤¤·¤Æ¤¤¤ë¡£
¤µ¤é¤Ë¡¢ºÇ¶á¤Ë¤Ê¤ê¡¢»ùƸ¡¦ÀÄǯ¤òÂоݤȤ·¤¿À½Â¤ÈÎÇä¸åÎ×¾²»î¸³Åù¤Ë¤Ä¤¤¤Æ¤â¤¬¹Ô¤Ê¤ï¤ì¤ë¤³¤È¤¬È½ÌÀ¤·¤¿¤Î¤Ç¡¢¤½¤ÎÃæ»ß¡¢¾ðÊó¸ø³«¤òµá¤á¤Æ¤¤¤¯¡£